MovDisordV3, Main, Exploration, bibRecord, 002D77

Levodopa for idiopathic restless legs syndrome: Evidence‐based review

Identifieur interne : 002D77 ( Main/Exploration ); précédent : 002D76; suivant : 002D78

Levodopa for idiopathic restless legs syndrome: Evidence‐based review

Auteurs : Cristiane Fiquene Conti [Brésil] ; Márcio Moysés De Oliveira [Brésil] ; Regis Bruni Andriolo [Brésil] ; Humberto Saconato [Brésil] ; Alvaro Nagib Atallah [Brésil] ; Juliana Spelta Valbuza [Brésil] ; Luciane Bizari Coin De Carvalho [Brésil] ; Gilmar Fernandes Do Prado [Brésil]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-10-15.

RBID : ISTEX:D9E4B7CCB74F24729C1EA9C3FEFBFAEF40F80DBD

English descriptors

KwdEn :
- Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Cross-Over Studies, Double-Blind Method, Evidence-Based Medicine, Humans, Levodopa (adverse effects), Levodopa (therapeutic use), Long-Term Care, Quality of Life, Randomized Controlled Trials as Topic, Restless Legs Syndrome (drug therapy), Restless Legs Syndrome (psychology), Treatment Outcome, augmentation, levodopa, restless legs syndrome, systematic review.
MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug therapy : Restless Legs Syndrome.
- psychology : Restless Legs Syndrome.
- Cross-Over Studies, Double-Blind Method, Evidence-Based Medicine, Humans, Long-Term Care, Quality of Life, Randomized Controlled Trials as Topic, Treatment Outcome.

Abstract

Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected body part. The prevalence of RLS is estimated at 2.7 to 5% of adults and it is more common in women. The treatment of RLS with levodopa has been reported thus a systematic synthesis of evidence is necessary to evaluate the effectiveness and safety of levodopa for RLS. Systematic review of randomized or quasi‐randomized, double blind trials on levodopa. Relief of restless legs symptoms marked on a validated scale, subjective sleep quality, sleep quality measured by night polysomnography and actigraphy, quality of life measured by subjective measures, adverse events associated with the treatments. Nine eligible clinical trials were included. The subjective analyses of these studies showed contradictory results, although the objective analyses showed that treatment group had a statistically significant improvement of periodic leg movement (PLM) index, favoring the treatment group. The most commonly adverse event seen was gastrointestinal symptoms. The short‐term treatment with levodopa was demonstrated effective and safety for PLM, but there was only few trials assessing long‐term treatment and the augmentation phenomenon in RLS. Further long‐term randomized controlled trials using standard follow‐up measurements as the International RLS Study Group Rating Scale are necessary. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/D9E4B7CCB74F24729C1EA9C3FEFBFAEF40F80DBD/fulltext/pdf

DOI: 10.1002/mds.21662

Affiliations:

Le document en format XML

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<author><name sortKey="Atallah, Alvaro Nagib" sort="Atallah, Alvaro Nagib" uniqKey="Atallah A" first="Alvaro Nagib" last="Atallah">Alvaro Nagib Atallah</name>
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<author><name sortKey="Valbuza, Juliana Spelta" sort="Valbuza, Juliana Spelta" uniqKey="Valbuza J" first="Juliana Spelta" last="Valbuza">Juliana Spelta Valbuza</name>
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<front><div type="abstract" xml:lang="en">Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected body part. The prevalence of RLS is estimated at 2.7 to 5% of adults and it is more common in women. The treatment of RLS with levodopa has been reported thus a systematic synthesis of evidence is necessary to evaluate the effectiveness and safety of levodopa for RLS. Systematic review of randomized or quasi‐randomized, double blind trials on levodopa. Relief of restless legs symptoms marked on a validated scale, subjective sleep quality, sleep quality measured by night polysomnography and actigraphy, quality of life measured by subjective measures, adverse events associated with the treatments. Nine eligible clinical trials were included. The subjective analyses of these studies showed contradictory results, although the objective analyses showed that treatment group had a statistically significant improvement of periodic leg movement (PLM) index, favoring the treatment group. The most commonly adverse event seen was gastrointestinal symptoms. The short‐term treatment with levodopa was demonstrated effective and safety for PLM, but there was only few trials assessing long‐term treatment and the augmentation phenomenon in RLS. Further long‐term randomized controlled trials using standard follow‐up measurements as the International RLS Study Group Rating Scale are necessary. © 2007 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

Levodopa for idiopathic restless legs syndrome: Evidence‐based review

Levodopa for idiopathic restless legs syndrome: Evidence‐based review

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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